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pentobarbital will decrease the extent or effect of parecoxib by impacting hepatic enzyme CYP2C9/ten metabolism. Use Caution/Observe.pentobarbital will lessen the extent or outcome of ketoconazole by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Slight/Significance Not known.If phenobarbital and doxycycline are administered concurrently,

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